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Why wait?
"NuCulture does its job."**
"Ground-breaking probiotic..."**
"NuCulture probiotics arrive alive"**

the probiotic of the future, with a free trial to prove it.

the probiotic of the future, with a free trial to prove it.

Protect Health. Support Digestion. Feel Great.

Try it free
NuCulture probiotic is made with 5 clinically
studied strains
and 15 billion CFUs in every capsule.

5 Reasons You Should
Take Probiotics Every Day

5 Reasons You Should Take Probiotics Everyday

1. Fight food cravings*

Taking probiotics can reduce your cravings for processed foods, sugar, and salt. You might even crave veggies instead!

2. Support your digestion*

Over 100 million Americans experience digestive problems. Good bacteria keep your digestive system healthy by breaking down food.

3. Reduce bloating*

No one feels like themselves when they're bloating. NuCulture supports digestive comfort and eliminates bad bacteria that cause gas.

4. Help good bacteria thrive*

The perfect belly balance is 85% good to 15% bad bacteria. NuCulture crowds out bad bacteria and effectively delivers the good guys.

5. Protect your health*

NuCulture probiotics fight alongside of your immune system to protect you from harmful bacteria. They also help maintain optimal health!

Eliminate The Bloat Before It Starts.

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Ingredients

5 powerful probiotics. 15 billion CFU. 1 revolutionary prebiotic.

"Spore form probiotics are the Chuck Norris of probiotics: total tough guys... Wimpier types -- including live cultures in yogurt -- often throw in the towel."
- Dr. Oz, 2011
Bacillus subtilis

Bacillus subtilis is a spore-forming probiotic, also known as a soil based probiotic. Spore-forming means that this strain forms a protective shell when exposed to harsh environments. These probiotics were abundant in our cave-dwelling ancestors' diet, but are absent in our modern diet. These resilient strains crowd out bad bacteria and promote digestive health.*

Bifidobacterium lactis

Bifidobacterium lactis is an important probiotic for immune health. There are 50 studies, 14 of which are clinical, on this specific strain. It enhances your immune function and your digestive flow. It may even help fight lactose intolerance too.*

Lactobacillus acidophilus

Lactobacillus acidophilus is the most popular probiotic. With 315 research studies and over 40 of which are clinical studies, this strain is incredible. It strengthens digestive and immune function. It's most known for helping you digest dairy and easing allergies.*

Bifidobacterium lactis

Another patented form of Bifidobacterium lactis, Bl-04 has 9 clinical studies demonstrating its efficacy. This probiotic overpowers bad bacteria and enhances your immune system. It helps maintain healthy respiratory function and overall health.*

Lactobacillus paracasei

Lactobacillus paracasei has over 10 clinical studies. This strain boosts immune function and digestive health. It even helps improve the bacterial balance in your belly. Studies suggest that this strain is perfect for children with digestive issues.*

Compare Probiotics

Not all probiotics are equal. NuCulture is a probiotic that makes a difference.
Made from goodness, our probiotic is free of sugar, fat, or scary additives.

Why a Free Trial?

It's our philosophy.

We believe you should be able to try it before you buy it. That's just how we think.

We're a small & humble company based out of Austin, TX. We're united with one clear goal: to create amazing products that work exceptionally well.

Our free trial is a leap of faith we're willing to take. Let's just say it's a testament to our complete confidence in our probiotic.

Questions? Talk to a specialist.

1-888-784-9315

Protect Health. Reduce Bloating. Feel Great.

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If You Aren't Taking Probiotics,
You Should Be. Here's Why:

Power of Probiotics

Your Immune System


  • Your stomach is home to 70% of your immune system.
  • Probiotics help you stay healthy by boosting immune response.*

Your Gut

  • For a healthier you, 85% of bacteria in your stomach should be good bacteria.
  • Probiotics crowd out bad bacteria so the good guys thrive.*

Your Gut Feeling


  • 95% of the feel-good hormone, serotonin, is found in your belly.
  • NuCulture helps promote gut comfort.*

The only probiotic powered by strains with 70+ clinical studies.

Try it free

We did the research, so you don't have to.

Lpc-37™
Lactobacillus paracasei

Human clinical studies

Gut function

1. Hemalatha R, Ouwehand AC, Forssten SD, Geddan JJB, Mamidi RS, Bhaskar V and Radhakrishna KV. 2014. A Community-based Randomized Double-Blind Controlled Trial of Lactobacillus paracasei and Bi dobacterium lactis on Reducing Risk for Diarrhea and Fever in Preschool Children in an Urban Slum in India. European Journal of Nutrition & Food Safety 4(4): 325-341. 

Also listed under Gastrointestinal ecology.

Immune system enhancement

1. Forssten SD, Salazar N, López P, Nikkilä J, Ouwehand AC, Patterson Á, Ruas-Madiedo P, Suarez A, Gonzalez S and Gueimonde M. 2011. In uence of a Probiotic Milk Drink, Containing Lactobacillus Paracasei Lpc-37, on Immune Function and Gut Microbiota in Elderly Subjects. European Journal of Food Research & Review. 1: 159-172.

Also listed under Gastrointestinal ecology.

2. Paineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. 2008. Effects of seven potential probiotic strains on speci c immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 53: 107-13.

3. Roessler A, Friedrich U, Vogelsang H, Bauer A, Kaatz M, Hipler UC, Schmidt I, Jahreis G. 2008. The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention. Clin Exp Allergy. 38: 93-102.

A Happy Heart

1. Trautvetter U,Ditscheid B,Kiehntopf M,Jahreis G. 2011. A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans. Clin Nutr. 2011 Oct 19.

Safety

1. Roessler A, Forssten SD, Glei M, Ouwehand AC, Jahreis G. 2011. The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: A randomized, placebo-controlled study. Clin Nutr. 2011 Sep 30.

Also listed under Gastrointestinal ecology.

Antibiotic associated diarrhea

1. Ouwehand AC, DongLian C, Weijian X, Stewart M, Ni J, Stewart T, Miller LE. 2014. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014 Jan 16;32(4): 458-63.

Gastrointestinal ecology

1. Hemalatha R, Ouwehand AC, Forssten SD, Geddan JJB, Mamidi RS, Bhaskar V and Radhakrishna KV. 2014. A Community-based Randomized Double-Blind Controlled Trial of Lactobacillus paracasei and Bi dobacterium lactis on Reducing Risk for Diarrhea and Fever in Preschool Children in an Urban Slum in India. European Journal of Nutrition & Food Safety 4(4): 325-341. 

Also listed under Gut function.

1. Mäkeläinen H, Saarinen M, Stowell J, Rautonen N and Ouwehand AC. 2010. Xylo-oligosaccharides and lactitol promote the growth of Bi dobacterium lactis and Lactobacillus species in pure cultures. Bene cial Microbes 1: 139-148.

2. Mäkeläinen H, Hasselwander O, Rautonen N, Ouwehand AC. 2009. Panose, a new prebiotic candidate. Lett Appl Microbiol. 49: 666-672.

Oral health

1. Lin X, Chen X, Chen Y, Jiang W, Chen H. 2014. The effect of ve probiotic lactobacilli strains on the growth and bio lm formation of Streptococcus mutans. Oral Dis. 2014 May 7. doi: 10.1111/odi.12257.

Genomics

1. Broadbent JR, Neeno-Eckwall EC, Stahl B, Tandee K, Cai H, Morovic W, Horvath P, Heidenreich J, Perna NT, Barrangou R, Steele JL. 2012. Analysis of the Lactobacillus casei supragenome and its in uence in species evolution and lifestyle adaptation. BMC Genomics. 2012 Oct 5;13: 533.

2. ForsstenSD,SalazarN,LópezP,NikkiläJ,Ouwehand AC, Patterson Á, Ruas-Madiedo P, Suarez A, Gonzalez S and Gueimonde M. 2011. In uence of a Probiotic Milk Drink, Containing Lactobacillus Paracasei Lpc-37, on Immune Function and Gut Microbiota in Elderly Subjects. European Journal of Food Research & Review. 1: 159-172.

Also listed under Immune system enhancement.

3. Roessler A, Forssten SD, Glei M, Ouwehand AC, Jahreis G. 2011. The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: A randomized, placebo-controlled study. Clin Nutr. 2011 Sep 30.

Also listed under Safety.

4. Engelbrektson AL, Korzenik JR, Pittler A, Sanders ME, Klaenhammer TR, Leyer G, Kitts CL. 2009. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol. 58: 663-670.

5. EngelbrektsonAL,KorzenikJR,SandersME,Clement B, Leyer G, Klaenhammer TR, Kitts CL. 2006. Analysis of treatment effects on the microbial ecology of the human intestine. FEMS Microbiol Ecol. 57: 239-250.

6. EngelbrektsonAL.2005.Analysisoftreatmenteffects on the microbial ecology of the gastrointestinal tract. PhD Thesis, California Polytechnic State University, San Luis Obispo, USA.

Synbiotic

1. Waitzberg DL, Logullo LC, Bittencourt AF, Torrinhas RS, Shiroma GM, Paulino NP, Teixeira-da-Silva ML. 2013. Effect of synbiotic in constipated adult women – A randomized, double-blind, placebo-controlled study of clinical response, Clinical Nutrition Clin Nutr. 32: 27-33.

NCFM®
Lactobacillus acidophilus

Human clinical studies

Safety

1. Cox AJ, West NP, Horn PL, Lehtinen MJ, Koerbin G, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults. Eur J Clin Nutr. 2014 Jul 23.

Gastrointestinal ecology

1. Forssten S, Evans M, Wilson D, Ouwehand AC. 2014. In uence of a probiotic mixture on antibiotic induced microbiota disturbances. World J Gastroenterol. 2014 Sep 7;20(33): 11878-85.

Also listed under Antibiotic associated diarrhea.

2. Ouwehand AC, Bruggencate SJ, Schonewille AJ, Alhoniemi E, Forssten SD, Bovee-Oudenhoven IM. 2014. Lactobacillus acidophilus supplementation in human subjects and their resistance to enterotoxigenic Escherichia coli infection. Br J Nutr. 2014 Feb;111(3): 465-73.

3. vanZantenGC,KrychL,RöytiöH,ForsstenS,Lahtinen SJ, Al-Soud WA,Sørensen S, Svensson B, Jespersen L, Jakobsen M. 2014. Synbiotic Lactobacillus acidophilus NCFM and cellobiose does not affect human gut bacterial diversity but increases abundance of lactobacilli, bi dobacteria and branched-chain fatty acids: a randomized, double-blinded cross-over trial. FEMS Microbiol Ecol. 2014 Aug 7.

4. Metsämarttila A. 2013. Ikääntyneiden suolistomikrobisto. MSc Thesis, Turku University [Finnish].

5. Björklund M, Ouwehand AC, Forssten SD, Nikkilä J, Tiihonen K, Rautonen N, Lahtinen SJ. 2011. Gut microbiota of healthy elderly NSAID users is selectively modi ed with the administration of Lactobacillus acidophilus NCFM and lactitol. Age (Dordr). 2011 Aug 19.

6. LahtinenSJ,ForsstenS,AakkoJ,GranlundL,Rautonen N, Salminen S, Viitanen M, Ouwehand AC. 2011. Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM modi es subpopulations of fecal lactobacilli and Clostridium dif cile in the elderly. Age (Dordr). 2011 Jan 25.

7. Larsen N, Vogensen FK, Gøbel R, Michaelsen KF, Al-Soud WA, Sørensen SJ, Hansen LH, Jakobsen M. 2010. Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bi dobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol. 2010 Nov 25. Also listed under Allerg y treatment.

8. Engelbrektson AL, Korzenik JR, Pittler A, Sanders ME, Klaenhammer TR, Leyer G, Kitts CL. 2009. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol. 58: 663-670.

9. Engelbrektson AL, Korzenik JR, Sanders ME, Clement B, Leyer G, Klaenhammer TR, Kitts CL. 2006. Analysis of treatment effects on the microbial ecology of the human intestine. FEMS Microbiol Ecol. 57: 239-250.

10. Engelbrektson AL. 2005. Analysis of treatment effects on the microbial ecology of the gastrointestinal tract. PhD Thesis, California Polytechnic State University, San Luis Obispo, USA.

11. Sui J, Leighton S, Busta F, Brady L. 2002. 16S ribosomal DNA analysis of the faecal lactobacilli composition of human subjects consuming a probiotic strain Lactobacillus acidophilus NCFM. J Appl Microbiol. 93: 907-912.

12. Varcoe J, Zook C, Sui J, Leighton S, Busta F, Brady L. 2002. Variable response to exogenous Lactobacillus acidophilus NCFM consumed in different delivery vehicles. J Appl Microbiol. 93: 900-906.

13. Crowell DC. 1998. Microbial analysis of human intestinal  ora after feeding Lactobacillus acidophilus. MSc Thesis, North Carolina State Univ., Raleigh.

14. Gilliland SW, Speck ML, Nauyok Jr, CF, Giesbrecht FG. 1978. In uence of consuming nonfermented milk containing Lactobacillus acidophilus on fecal  ora of healthy males. J Dairy Sci. 61: 1-10.

15. Gilliland SE, Speck ML, Morgan CG. 1975. Detection of Lactobacillus acidophilus in feces of humans, pigs and chickens. Appl Microbiol. 30: 541-545. Also listed under Animal trials Probiotic selection, survival, stability.

Small bowel bacterial overgrowth

1. Dunn SR, Simenhoff ML, Ahmed KE, Gaughan WJ, Eltayeb BO, Fitzpatrick MED, Emery SM, Ayres JW, Holt KE. 1998. Effect of oral administration of freeze-dried Lactobacillus acidophilus on small bowel bacterial overgrowth in patients with end stage kidney disease: reducing uremic toxins and improving nutrition. Int Dairy J. 8: 545-553.

2. Simenhoff ML, Dunn SR. 1996. Altered gut  ora in uremia. J Renal Nutr. 6: 68-74.

3. Simenhoff ML, Dunn SR, Zollner GP, Fitzpatrick MED, Emery SM, Sandine WE, Ayres JW. 1996. Biomodulation of the toxic and nutritional effects of small bowel bacterial overgrowth in end-stage kidney disease using freeze-dried Lactobacillus acidophilus. Mineral and Electrolyte Metab. 22: 92-96. [Strain LBA = NCFM]

Synbiotic

1. Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, Barcelos IK, Leal RF, Ayrizono Mde L, Fagundes JJ, Teixeira Lde B, Ouwehand AC, Coy CS. 2014. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bi dobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014 Jul 24;13:75.

Also listed under Gastrointestinal functionality.

2. Waitzberg DL, Logullo LC, Bittencourt AF, Torrinhas RS, Shiroma GM, Paulino NP, Teixeira-da-Silva ML. 2013. Effect of synbiotic in constipated adult women – A randomized, double-blind, placebo-controlled study of clinical response Clin Nutr. 32: 27-33.

3. Wang S, Zhu H, Lu C, Kang Z, Luo Y, Feng L, Lu X. 2012. Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals. J Dairy Sci. 2012 Sep;95(9): 4813-4822.

4. Ouwehand AC, Tiihonen K, Saarinen M, Putaala H, Rautonen N. 2009. In uence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters. Br J Nutr. 101: 367-375.

5. Schrezenmeir J, Heller K, McCue M, Llamas C, Lam W, Burow H, Kindling-Rohracker M, Fischer W, Sengespeik HC, Comer GM, Alarcon P. 2004. Bene ts of oral supplementation with and without synbiotics in young children with acute bacterial infections. Clin Ped. 43: 239-249.

6. Fisberg M, Maulén-Radován IE, Tormo R, Carrascoso MT, Giner CP, Martin FA, et al. 2002. Effect of oral nutritional supplementation with or without synbiotics and sickness and catch-up growth in preschool children. Int Pediatr. 17: 216-222.

7. Swanson KS, Grieshop CM, Flickinger EA, Bauer LL, Wolf BW, Chow J, Garleb KA, Williams JA, Fahey Jr, GC. 2002. Fructooligosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy humans. J Nutr. 132: 3042-3050.

Immune system enhancement

1. Ibrahim F, Ruvio S, Granlund L, Salminen S, Viitanen M, Ouwehand AC. 2010. Probiotics and immunosenescence: cheese as a carrier. FEMS Immunol Med Microbiol. 59: 53-59.

2. Paineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. 2008. Effects of seven potential probiotic strains on speci c immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 53: 107-13.

Allergy treatment

1. Gobel R, Larsen N, Molgaard C, Jakobsen M, Michaelsen KF. 2010. Probiotics to young children with atopic dermatitis: A randomized placebo-controlled trial. Int J Prob Preb. 5: 53-60.

2. Larsen N, Vogensen FK, Gøbel R, Michaelsen KF, Al-Soud WA, Sørensen SJ, Hansen LH, Jakobsen M. 2010. Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bi dobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol. 2011 75: 482-496.

Also listed under Gastrointestinal ecolog y.

3. Ouwehand AC, Nermes M, Collado MC, Rautonen N, Salminen S, Isolauri E. 2009. Speci c probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterol. 15: 3261-3268.

Anti-carcinogenic activity

1. Goldin BR, Gorbach SL. 1984. The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity. Amer J Clin Nutr. 39: 756-761.

2. Goldin BR, Gorbach SL. 1984. The effect of oral administration of Lactobacillus and antibiotics on intestinal bacterial activity and chemical induction of large bowel tumors. Dev Indus Microbiol. 25: 139-150.

Also listed under Animal trials.

3. Goldin BR, Swenson L, Dwyer J, Sexton M, Gorbach S. 1980. Effect of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes. J Natl Cancer Instit. 64: 255-261.

Cholesterol lowering

1. Thompson LU, Jenkins DJA, Amer MAV, Reichert R, Jenking A, Kamulsky J. 1982. The effect of fermented and unfermented milks on serum cholesterol. Amer J Clin Nutr. 36: 1106-1111.

Insulin sensitivity

1. Andreasen AS, Larsen N, Pedersen-Skovsgaard T, Berg RM, Møller K, Svendsen KD, Jakobsen M, Pedersen BK. 2010. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic in ammatory response in human subjects. Br J Nutr. 104: 1831-1838.

Improved lactose digestion

1. Mustapha A, Jiang T, Savaiano DA. 1997. Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk: In uence of bile sensitivity, lactose transport, and acid tolerance of Lactobacillus acidophilus. J Dairy Sci 80: 1537-1545. [Strain LA-1 = NCFM]

2. Montes RG, Bayless TM, Saavedra JM, Perman JA. 1995. Effect of milks inoculated with Lactobacillus acidophilus or a yogurt starter culture in lactose-maldigesting children. J Dairy Sci. 78: 1657-1664.

3. Lin MY, Savaiano D, Harlander S. 1991. In uence of nonfermented dairy products containing bacterial starter cultures on lactose maldigestion in humans. J Dairy Sci. 74: 87-95.

4. McDonough FE, Hitchins AD, Wong NP, Wells P, Bodwell CE. 1987. Modi cation of sweet acidophilus milk to improve utilization by lactose-intolerant persons. Am J Clin Nutr. 45: 570-574.

5. Savaiano DA, Abou El Anouar DAG, Smith DE, Levitt MD. 1984. Lactose malabsorption from yogurt, pasteurized yogurt, sweet acidophilus milk, and cultured milk in lactase-de cient individuals. Amer J Clin Nutr. 40: 1219-1223.

6. Kim GS, Gilliland SE. 1983. Lactobacillus acidophilus as a dietary adjunct for milk to aid lactose digestion in humans. J Dairy Sci. 66: 959-966.

7. Newcomer AD, Park HS, O’Brien PC, McGill DB. 1983. Response of patients with irritable bowel syndrome and lactase de ciency using unfermented acidophilus milk. Amer J Clin Nutr. 38: 257-263.

8. Payne DL, Welsh JD, Manion CV, Tsegaye A, Herd LD. 1981. Effectiveness of milk products in dietary management of lactose malabsorption. Amer J Clin Nutr. 34: 2711-2715.

General health

1. West NP, Horn PL, Barrett S, Warren HS, Lehtinen MJ, Koerbin G, Brun M, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Supplementation with a single and double strain probiotic on the innate immune system for respiratory illness. e-SPEN Journal 9: e178-e184.

2. West NP, Horn PL, Pyne DB, Gebski VJ, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr 33(4): 581-7.

3. Hietikko E. Probioottien vaikutus ikääntyneiden ravitsemustilaan ja terveyteen liittyvään elämänlaatuun: Pilottitutkimus MNA- ja 15D-mittareiden käytöstä probioottitutkimuksessa. MSc Thesis, Turku University. [Finnish]

4. LeyerGJ,LiS,MubasherME,ReiferC,OuwehandAC. 2009. Probiotic effects on cold and in uenza-like symptom incidence and duration in children. Pediatrics. 124: e172-e179. Also listed under Synbiotic: Fisberg et al. 2004 and Schrezenmeir et al. 2002.

Antibiotic associated diarrhea

1. Forssten S, Evans M, Wilson D, Ouwehand AC. 2014. In uence of a probiotic mixture on antibiotic induced microbiota disturbances. World J Gastroenterol. 2014 Sep 7;20(33): 11878-85. Also listed under Gastrointestinal ecology.

2. Ouwehand AC, DongLian C, Weijian X, Stewart M, Ni J, Stewart T, Miller LE. 2014. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014 Jan 16;32(4): 458-63.

Gastrointestinal functionality

1. D’Souza B, Slack T, Wong SW, Lam F, Muhlmann M, Koestenbauer J, Dark J, Newstead G. Randomized controlled trial of probiotics after colonoscopy. ANZ J Surg. 2015 Jul 17.

2. Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, Barcelos IK, Leal RF, Ayrizono Mde L, Fagundes JJ, Teixeira Lde B, Ouwehand AC, Coy CS. 2014. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bi dobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014 Jul 24;13:75.

Also listed under Synbiotic.

3. Ringel-Kulka T, Goldsmith JR, Carroll IM, Barros SP, Palsson O, Jobin C, Ringel Y. 2014. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain – a randomised clinical study. Aliment Pharmacol Ther. 2014 May 22. doi: 10.1111/apt.12800.

4. Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, Leyer G and Ringel Y. 2011. Probiotic Bacteria: Probiotic Bacteria Lactobacillus acidophilus NCFM and Bi dobacterium lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients With Functional Bowel Disorders-a Double-blind Study. J Clin Gastroenterol. 45: 518-525.

5. Faber S. 2006. Response to a comment on “The use of probiotics in the treatment of irritable bowel syndrome”. Altern Ther Health Med. 12: 17. [Correspondence]

6. Faber S, Rigden S, Lukaczer D. 2005. The use of probiotics in the treatment of irritable bowel syndrome: two case reports. Altern Ther Health Med. 11: 60-62.

7. Heiser CR, Ernst JA, Barrett JT, French N, Schutz M, Dube MP. 2004. Probiotics, soluble  ber, and L-Glutamine (GLN) reduce nel navir (NFV) – or lopinavir/ritonavir (LPV/r)-related diarrhea. J Int Assoc Physicians AIDS Care (Chic Ill ). 3: 121-129.

8. Faber SM. 2003. Are probiotics useful in irritable bowel syndrome? J Clin Gastroenterol. 37: 93-94.

9. Lukaczer D. Evaluating the Effects of Specialized Nutritional Support, Including strain-certi ed Lactobacillus acidophilus NCFM and Bi dobacterium lactis BI-07, in a Patient with Irritable Bowel Syndrome. (Case study #1150). San Clemente (CA): Metagenics, Inc. See  le “metagenics search ncfm” – Several case studies exist, but not all available in full text. No 1150 available. [Case studies]

Bl-04™
Bifidobacterium lactis

Human clinical studies

Safety

1. Cox AJ, West NP, Horn PL, Lehtinen MJ, Koerbin G, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults. Eur J Clin Nutr. 2014 Jul 23.

Antibiotic associated diarrhea

1. Ouwehand AC, DongLian C, Weijian X, Stewart M, Ni J, Stewart T, Miller LE. 2014. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014 Jan 16;32(4): 458-63.

Gastrointestinal ecology

1. Engelbrektson AL, Korzenik JR, Pittler A, Sanders ME, Klaenhammer TR, Leyer G, Kitts CL. 2009. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol. 58: 663-670.

2. Engelbrektson AL, Korzenik JR, Sanders ME, Clement B, Leyer G, Klaenhammer TR, Kitts CL. 2006. Analysis of treatment effects on the microbial ecology of the human intestine. FEMS Microbiol Ecol. 57: 239-250.

3. BartoschS,WoodmanseyEJ,PatersonJC,McMurdo ME, Macfarlane GT. 2005. Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis. 40: 28-37. [Strain BL01 = Bl-04]

4. EngelbrektsonAL.2005.Analysisoftreatmenteffects on the microbial ecology of the gastrointestinal tract. PhD Thesis, California Polytechnic State University, San Luis Obispo, USA.

Immune system enhancement

1. Paineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. 2008. Effects of seven potential probiotic strains on speci c immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 53: 107-13.

Allergy treatment

1. Ouwehand AC, Nermes M, Collado MC, Rautonen N, Salminen S, Isolauri E. 2009. Speci c probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterol. 2009 15: 3261-8.

General health

1. West NP, Horn PL, Barrett S, Warren HS, Lehtinen MJ, Koerbin G, Brun M, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Supplementation with a single and double strain probiotic on the innate immune system for respiratory illness. e-SPEN Journal 9: e178-e184.

2. West NP, Horn PL, Pyne DB, Gebski VJ, Lahtinen SJ, Fricker PA, Cripps AW. 2013. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr. 2014 Aug;33(4): 581-7.

Bi-07™
Bifidobacterium lactis

Human clinical studies

Safety and colonization

1. Cox AJ, West NP, Horn PL, Lehtinen MJ, Koerbin G, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW. Effects of probiotic supplementation over 5months on routine haematology and clinical chemistry measures in healthy active adults. Eur J Clin Nutr. 2014 Jul 23.

2. Bettler J, Mitchell DK, Kullen MJ. 2006.Administration of Bifidobacterium lactis with fructose-oligosaccharide to toddlers is safe and results in transient colonization. Int J Prob Preb. Vol. 1; No. 3/4.

Antibiotic associated diarrhea

1. Forssten S, Evans M, Wilson D, Ouwehand AC. 2014. Influenceofaprobioticmixtureonantibioticinduced microbiota disturbances. World J Gastroenterol. 2014 Sep 7;20(33): 11878-85.

Also listed under Gastrointestinal ecology.

2. Ouwehand AC, Dong Lian C, Weijian X, Stewart M, Ni J, Stewart T, Miller LE. 2014. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014 Jan 16;32(4): 458-63.

Gastrointestinal ecology

1. Forssten S, Evans M, Wilson D, Ouwehand AC. 2014. Influence of a probiotic mixture on antibiotic induced microbiota disturbances. World J Gastroenterol. 2014 Sep 7;20(33): 11878-85.

Also listed under Antibiotic associated diarrhea.

2. Larsen N, Vogensen FK, Gøbel R, Michaelsen KF, Al-Soud WA, Sørensen SJ, Hansen LH, Jakobsen M. 2010. Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol. 75: 482-496.

Also listed under Allergy treatment.

3. Engelbrektson AL, Korzenik JR, Pittler A, Sanders ME, Klaenhammer TR, Leyer G, Kitts CL. 2009. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol. 58: 663-670.

4. Engelbrektson AL, Korzenik JR, Sanders ME, Clement B, Leyer G, Klaenhammer TR, Kitts CL. 2006. Analysis of treatment effects on the microbial ecology of the human intestine. FEMS Microbiol Ecol. 57: 239-250.

5. EngelbrektsonAL.2005.Analysisoftreatmenteffects on the microbial ecology of the gastrointestinal tract. PhD Thesis, California Polytechnic State University, San Luis Obispo, USA.

Synbiotic

1. Childs CE, Röytiö H, Alhoniemi E, Fekete AA, Forssten SD, Hudjec N, Lim YN, Steger CJ, Yaqoob P, Tuohy KM, Rastall RA, Ouwehand AC and Gibson GR. 2014. Xylo- oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study. Br J Nutr. 2014 Mar 24: 1-12.

2. Wang S, Zhu H, Lu C, Kang Z, Luo Y, Feng L, Lu X. 2012. Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals. J Dairy Sci. 2012 Sep;95(9): 4813-4822.

3. Schrezenmeir J, Heller K, McCue M, Llamas C, Lam W, Burow H, Kindling-Rohracker M, Fischer W, Sengespeik HC, Comer GM, Alarcon P. 2004. Benefits of oral supplementation with and without synbiotics in young children with acute bacterial infections. Clin Ped. 43: 239-249.

4. Fisberg M, Maulén-RadovánI E, Tormo R, Carrascoso MT, Giner CP, Martin FA, et al. 2002. Effect of oral nutritional supplementation with or without synbiotics and sickness and catch-up growth in preschool children. Int Pediatr. 17: 216-222.

Immune system enhancement

1. Maneerat S, Lehtinen MJ, Childs CE, Forssten SD, Alhoniemi E, Tiphaine M, Yaqoob P, Ouwehand AC and Rastall RA. 2013. Consumption of Bifidobacteriumlactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes. Journal of Nutritional Science, vol. 2, e44: 1-10. Supplementary data included. Erratum in Journal of Nutritional Science (2014), vol. 3, e4: 1-3.

2. Paineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. 2008. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS ImmunolMedMicrobiol.53:107-13.

Allergy treatment

1. Gobel R, Larsen N, Molgaard C, Jakobsen M, Michaelsen KF. 2010. Probiotics to young children with atopic dermatitis: A randomized placebo-controlled trial. Int J Prob Preb. 5: 53-60.

2. Larsen N, Vogensen FK, Gøbel R, Michaelsen KF, Al-Soud WA, Sørensen SJ, Hansen LH, Jakobsen M. 2010. Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol. 75: 482-496.

Also listed under Gastrointestinal ecolog y.

General health

1. West NP, Horn PL, Barrett S, Warren HS, Lehtinen MJ, Koerbin G, Brun M, Pyne DB, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Supplementation with a single and double strain probiotic on the innate immune system for respiratory illness. e-SPEN Journal 9: e178-e184.

2. West NP, Horn PL, Pyne DB, Gebski VJ, Lahtinen SJ, Fricker PA, Cripps AW. 2014. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physicallyactiveindividuals.ClinNutr33(4):581-7.

3. LeyerGJ,LiS,MubasherME,ReiferC,OuwehandAC. 2009. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics 124: e172-e179. Also listed under Synbiotic: Fisberg et al. 2004 and Schrezenmeir et al. 2002.

Gastrointestinal functionality

1. D’Souza B, Slack T, Wong SW, Lam F, Muhlmann M, Koestenbauer J, Dark J, Newstead G. 2015. Randomized controlled trial of probiotics after colonoscopy. ANZ J Surg. 2015 Jul 17.

2. Ringel-Kulka T, Goldsmith JR, CarrollI M, Barros SP, Palsson O, Jobin C, Ringel Y. 2014. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain – a randomised clinical study. Aliment Pharmacol Ther. 2014 May 22. doi: 10.1111/apt.12800.

3. Favretto DC, Pontin B, Moreira TR. 2013. Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis bi-07) in improving symptoms of constipation. Arq Gastroenterol. 50: 196-201.

4. Ringel-KulkaT,PalssonO,MaierD,CarrollI,Galanko JA, Leyer G, Ringel Y, 2011. Probiotic Bacteria: Probiotic Bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients With Functional Bowel Disorders-a Double-blind Study. J Clin Gastroenterol. 45: 518-525.

5. Faber S. 2006. Response to a comment on “The use of probiotics in the treatment of irritable bowel syndrome”. Altern Ther Health Med. 12: 17. [Correspondence]

6. Faber S, Rigden S, Lukaczer D. 2005. The use of probiotics in the treatment of irritable bowel syndrome: two case reports. Altern Ther Health Med. 11: 60-62.

7. Lukaczer D. Evaluating the Effects of Specialized Nutritional Support, Including strain-certified Lactobacillus acidophilus NCFM and Bifidobacterium lactis BI-07, in a Patient with Irritable Bowel Syndrome. (Case study #1150). San Clemente (CA): Metagenics, Inc. [Case studies]

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